Our international collaborative project The Pan-Cancer Proteome Atlas has been published in Cancer Cell!
- Post by: OPL
- May 30, 2025
- Comments off
The idea was conceived at the HUPO 2017 meeting where Tiannan Guo and Connie Jimenez decided to join forces to create a large pan-cancer landscape using DIA-MS. With the HTP capabilities and robustness of the innovative DIA approach, the time was right to perform a large-scale study across multiple tumor types instead of profiling single tumor types as was done to date.
Highlights:
- Pan-cancer proteome of almost 10.000 proteins across 18 solid and 4 liquid cancers from 999 human samples
- Tissue type biology influences, but does not fully determine, tumor classification
- Co-expressed pan-cancer proteins and biology with potential therapeutic utility
- Cancer (sub)type enrichment reveals new proteins with biomarker potential
- CMS proteins and immune subtypes with prognostic value in colorectal cancer
- Multi-cancer classifier for identification of metastasis of unknown primary origin
Altogether, our approach identifies well-established and novel protein biomarkers of cancer (sub)types and, more importantly, highlights key proteins that together enable cancer type classification. Via the data portal (http://r2platform.com/TPCPA ), it offers a queryable treasure trove of data for hypotheses for more specifically targeted research.
Link to the article: https://doi.org/10.1016/j.ccell.2025.05.003
For more information, see the press release and a LinkedIn post.