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Our study published Feb. 25 in Nature Communications shows that phosphoproteomic profiling can discover novel targets for therapy for T-ALL and it can guide the design of treatment combination strategies when a single therapy is not sufficient. The analysis of active proteins gives us a more complete picture of the leukemia and allows for selection […]

Zhu T, Zhu Y, Xuan Y, Gao H, Cai X, Piersma SR, Pham TV, Schelfhorst T, Haas RRGD, Bijnsdorp IV, Sun R, Yue L, Ruan G, Zhang Q, Hu M, Zhou Y, Van Houdt WJ, Le Large TYS, Cloos J, Wojtuszkiewicz A, Koppers-Lalic D, Böttger F, Scheepbouwer C, Brakenhoff RH, van Leenders GJLH, Ijzermans JNM, […]

16 November 2021 15:45 Fine-tuning prediction of response and survival in acute myeloid leukemia PhD defence by D.G.J. Cucchi

This progress report 2018-2021 covers proteomics research of the OncoProteomics Laboratory (OPL) and collaborators, as well as proteomics activities performed in the context of our function as Proteomics Core Facility. It harbors information on our mass spectrometry infrastructure and proteomics expertise, output, academic activities and includes summaries of running core and collaborative projects.

After the first Annals of Internal Medicine paper describing the proteomics discovery and validation of stool protein for colorectal cancer screening, we now are proud to report the follow-up large scale validation in FIT samples using antibodies. again published in Annals of Internal Medicine. Bosch LJW, de Wit M, Pham TV, Coupé VMH, Hiemstra AC, […]

Alexia, Elena, and Merih and learned all about proteomics and performed an experiment on their own samples as well as some Dutch highlights.

You throw away leftovers after RNA isolation? Save them and consider performing proteomics. The team of Connie Jimenez could show that RNA-Bee derived protein fractions are very suitable for phosphorylation analysis. In daily practice, different types of biomolecules are usually extracted for large-scale “omics” analysis with tailored protocols. However, when sample material is limited, an […]

Week 1 of the course will be on-line and provide participants with a global insight into the field of proteomics, its theory and applications in biomedical research. One day will be dedicated to bioinformatics tools for (prot)eomics data analysis Week 2 will provide participants with hands-on experience with a proteomics experiment and data analysis. Click […]

The students were highly motivated, happy to be able to do the practial part on-site and all did very well.

The European Proteomics Association (EuPA) (www.eupa.org) is a federation of European 21 national proteomics societies. EuPA aims to strengthen and promote fundamental research and applications, as well as education and training in all areas of proteomics throughout Europe. Connie looks forward to help shape ambitious plans for the coming 3 years that will be carried […]