Monthly Archives: September 2023

Connie Jimenez, The Netherlands   What is your current position and location? I am full Professor of Translational OncoProteomics, Principle Investigator of the OncoProteomics Laboratory and Director of the Proteomics Core Resource, all at Amsterdam University Medical Center, in the beautiful city Amsterdam where I was born, in The Netherlands. How did you get started […]

Can mass spectrometry-based phosphoproteomics help understand the (lack of) response to EGFR-blockade and identify predictive markers and new treatment options? We analyzed a unique collection of 29 molecularly characterized colorectal patient-derived xenograft (PDX) tumors, annotated for cetuximab response. Proteomics identified CXADR as promising marker of treatment response, while phosphoproteomics coupled to single sample kinase activity […]